4-(4-methylpiperazine-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl) Amino] Teflon Acetate

 

4-(4-methylpiperazine-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl) Amino] Teflon Acetate ,which CAS number is 1034975-62-6,is an intermeidates of Entrectinib.Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.mainly used for the treatment of adults and children with advanced recurrent solid tumors that are positive for neurotrophic tyrosine receptor kinase (NTRK) fusion;And for the treatment of metastatic non-small cell lung cancer carrying mutations in the ROS1 gene.

 

Jinan Tantu Chemicals Co., Ltd. is a CDMO company serving global pharmaceutical companies, providing custom R&D and production of small molecule pharmaceutical intermediates and APIs for international and domestic pharmaceutical companies, with capabilities ranging from laboratory kilogram to commercial ton scale production. Jinan Tantu Chemical Co., Ltd. is also dedicated to the independent research and development, production and sales of high-end pharmaceutical intermediates and API products.mainly products:Ceftaroline Fosamil,Ceftobiprole Medocaril,Tebipenem side chain,Lifitegrast,Larotrectinib,Entrectinib,Etc.

Main business

• Anti-tumor, anti-infection, anti-virus, kidney disease, antibiotics, ophthalmic drug intermediates advantage supplier;
• CDMO&CMO
•  Integrated innovative R&D platform for intermediates & apis;
• Development and synthesis of innovative drugs/generic drug intermediates/special chemicals/molecular blocks;
• immature intermediates process optimization and industrialization amplification, product CMO;
• Manufactures and sells its own commercial intermediates and molecular blocks;
• Total quality research, CMC, route design and product development, process transfer;

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http://www.tantuchemicals.com/